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Diabetes risk: Even a high-fat meal negatively affects the metabolism

Diabetes risk: Even a high-fat meal negatively affects the metabolism


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Negative metabolic changes even from a high-fat meal
More and more Germans suffer from diabetes. In the meantime, almost seven million people with so-called diabetes live in this country. Scientific studies have now shown that a high-fat meal can cause negative metabolic changes, which in turn promote the development of type 2 diabetes.

Problems with glucose metabolism
Around 6.7 million people in Germany are currently diagnosed with diabetes, more than 95 percent of them with type 2 diabetes, and the trend is rising. Clinics also show that the number of diabetes patients continues to rise. According to a message from the German Diabetes Society, half of all patients treated in the hospital have problems with their glucose metabolism, be it because they already have diabetes or a preliminary stage.

Even a high-fat meal can cause negative metabolic changes
As the company reports, the German Center for Diabetes Research (DZD) is presenting new findings on the development and early detection of diabetes mellitus at the Diabetes Congress in Hamburg.

The German Diabetes Center in Düsseldorf and the Helmholtz Center Munich demonstrated in a high-fat diet study carried out in parallel on mice and humans that even a high-fat meal can cause negative metabolic changes, which in turn promote the development of type 2 diabetes.

“The Düsseldorf researchers examined the effects of a high-fat diet in humans. At the Helmholtz Zentrum München, the investigations were carried out in parallel using the mouse model, ”explained Professor Dr. Dr. h.c. Martin Hrabe de Angelis, board member of the DZD and director of the Institute for Experimental Genetics at the Helmholtz Zentrum München.

The liver's energy balance changed
According to the information, the human study participants - healthy slim men - were randomly given one flavored palm oil drink and another glass of clear water as a control experiment.

The palm oil drink contained a similar amount of saturated fat as two cheeseburgers with bacon and a large portion of french fries or two salami pizzas. The mice also received palm oil.

"It was shown in both humans and mice that this single high-fat meal is sufficient to reduce the insulin effect, that is, to cause insulin resistance and to increase the fat content of the liver," says Professor Hrabe de Angelis.

“The liver's energy balance also changed. These metabolic changes are similar to those seen in people with type 2 diabetes or non-alcoholic fatty liver disease (NAFLD). ”

In addition, the mouse model has shown that palm oil changes the expression of genes that regulate inflammatory and protective metabolic pathways.

The results of the study were published in the journal "Clinical Investigation". (ad)

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