Eating fructose has many negative health consequences

What type of sugar is the most unhealthy?
Consuming too much sugar is not good for our health. Researchers have now found that not only the amount, but also the type of sugar consumed, can have serious health effects. Fructose appears to be particularly harmful.

The University of Barcelona scientists found that eating fructose is particularly detrimental to metabolism and the vascular system compared to consuming glucose. The doctors published the results of their study in the journal "American Journal of Physiology-Heart and Circulatory Physiology".

Fructose damages the metabolism and the vascular system
The current study examined the dangers that glucoe and fructose can pose to human health. The results show that the consumption of fructose leads to more damaging effects on the metabolism and the vascular system, glucose, explain the experts. Fructose is a type of sugar that is also known as fructose. In nature, fructose occurs primarily in fruits such as apples, pears and berries.

Fructose has a high amount of sweeteners and low production costs
Fructose is simple sugar (monosaccharide) that is commonly found in fruits. This type of sugar is one of the most common sweeteners in the food industry. It has a high amount of sweetener and low production costs compared to sugar from sucrose or corn syrup with fructose, the researchers explain in a press release.

Doctors test the health effects of sugar in animal models
In the current study, the scientists found that female rats are more sensitive to the metabolic changes than male rats. In addition to their normal diet, the test rats also received glucose or fructose-liquid complementation. Depending on the type of sugar consumed (glucose or fructose), the experimental animals showed differences in body weight, triglycerides and vascular physiology, the experts explain.

What did fructose do in the experiment?
One of the outstanding metabolic effects is the high concentration of triglycerides in the plasma of the group of rats given fructose, the authors say. This effect cannot only be explained by a large synthesis of liver lipids, since both glucose and fructose induce hepatic lipogenesis, the scientists further explain. The protein content of a key enzyme in fatty acid oxidation (CPT1A) only decreased in the rats that received fructose.

This group also showed an increase in the expression of a protein called MTP, which helps to transport triglycerides from the liver to the plasma. The observed effects suggest that fructose is able to reduce the oxidation of fatty acids and increase the movement of triglycerides from the liver into the plasma in a certain way, the researchers explain. A so-called hypertriglyceridaemia presumably causes these effects.

Fructose leads to vascular and hepatic changes
When rats are given glucose, the aorta's ability to relax when exposed to an active ingredient with nitric oxide (sodium nitroprusside) increases, the authors say. This ability of the aorta was less in the rats from the fructose group. From a vascular perspective, this shows that fructose has a negative effect on the relaxation of the aorta. Glucose has a more beneficial effect here, the scientists add. The rats given fructose also showed changes in their liver and gained weight faster. Previous studies had shown that taking fructose in rats was associated with hepatic changes.

Fructose can lead to a so-called fatty liver in male and female rats. Aside from the vascular and hepatic changes noted, there is a greater increase in body weight in these rats, even though they consumed fewer calories than the rats in the other group.

Inflammation can be triggered by an increased intake of fructose
The fact that fructose reduces the oxidation of fatty acids and increases the synthesis of liver lipids can lead to an increase in what is known as lipid deposition in the organ (fatty liver), the experts say. This accumulation of lipids in the liver can in turn lead to inflammation of the liver.

Fructose can have a massive impact on the body
At first glance, the body weight gain that appears appears to be connected only with the increase in calorie intake, but other factors are also involved, the authors explain. In particular, the weight gain in the liver, which was found in the fructose group of the rats, could be related to the accumulation of lipids in this organ and could have a massive impact on the body, according to the researchers. (as)

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