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Caries also due to genetic defects: brushing your teeth does not only protect against caries

Caries also due to genetic defects: brushing your teeth does not only protect against caries


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Gene defects in tooth enamel favor the formation of caries
Health experts are constantly pointing out that regular tooth brushing is the most effective measure to prevent tooth decay efficiently, but researchers in Switzerland have now found that genetic defects in tooth enamel can also promote tooth decay.

Tips for dental health
When it comes to good oral hygiene, it is often emphasized how important nutrition is. What is meant is not only the reduction in sugar consumption, but also the protective function of certain foods. Studies have shown, for example, that beetroot juice helps prevent tooth decay and that vegetable juice made from arugula, spinach and Swiss chard is also suitable for good dental health. However, brushing teeth is the most important contribution to protecting against tooth decay. But for some people that is obviously not enough.

Mutated genes can lead to defects in the tooth enamel
Life is often unfair: While some people always brush their teeth diligently and still get tooth decay, others do not take oral hygiene very seriously and have no holes.

Even though there are bacteria on both of them on the tooth surface that can attack the enamel. However, researchers at the University of Zurich have now found that tooth decay is not only caused by bacteria.

As the Swiss university reports in a communication, mutated genes can lead to defects in tooth enamel and thus contribute to caries development.

Caries is not only related to bacteria
The two teams from the Center for Dentistry and the Institute for Molecular Biology identified a gene complex that is responsible for the formation of tooth enamel.

They were able to show that mice with changes in the genetic makeup of certain enamel proteins had defects in their teeth. According to the scientists, the hardness and composition of the tooth enamel can affect the progression of caries.

"We have shown that tooth decay is not only related to bacteria, but is also linked to the resilience of the tooth," said Thimios Mitsiadis, professor of oral biology from the Center for Dentistry.

Significantly improve oral health
Bacteria and their toxic products could easily penetrate a tooth enamel with a less stable structure. This leads to carious lesions, even if oral hygiene is observed.

According to the researchers, understanding the molecular-biological relationships of tooth enamel development and the effects of mutations that lead to enamel defects opens up new opportunities for caries prevention.

"Thanks to new products that prevent dental caries from progressing if the tooth enamel is defective, we will be able to significantly improve the oral health of those affected," added the expert. (ad)

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