Study examines the possible reasons for the development of Alzheimer's
Physicians have come a step closer to understanding the development of Alzheimer's. Researchers from the University of Texas Medical Branch have now found that there is an important relationship between inflammation, a toxic protein, and the onset of Alzheimer's disease. The new findings could enable doctors to identify signs of Alzheimer's disease at an early stage.
The University of Texas Medical Branch researchers found that there is a link between certain inflammations, a toxic protein, and the onset of Alzheimer's. The doctors released a press release on the results of their study.
New studies could prevent brain cell loss and cognitive decline
The results of the examination identified a method that will enable doctors to recognize signs of Alzheimer's early on. For this, the doctors have to examine the back of the eyes of those affected, the researchers explain. Early detection of so-called warning signs for Alzheimer's can enable early intervention and prevention of neurodegeneration before brain cell loss and cognitive decline occur, according to study author Ashley Nilson.
New investigation is quick and inexpensive
Using the retina to detect Alzheimer's and other neurodegenerative diseases is non-invasive, inexpensive, and can be done as part of a normal exam, doctors say. Researchers had previously found evidence that a toxic form of tau proteins can underlie early stages of Alzheimer's.
What happens in Alzheimer's?
In the case of Alzheimer's disease, existing tau protein in the human body turns into a toxic form, the experts say. These are called tau oligomers. In addition, lumps begin to form in the neurofibrils. This means that nutrients can no longer be transported to where they are actually needed, the researchers explain. In addition, the oligomers have toxic effects, which ultimately lead to the death of the brain cells.
Inflammation in the brain plays a very important role in the development of Alzheimer's
Scientists emphasize that it is becoming increasingly clear that inflammation in the brain plays an important role in the development and progression of Alzheimer's. Inflammation and the loss of connections between nerves in the brain arise before the formation of so-called fibrils, which are characteristic of this disease, the scientists say. It is quite possible that the tau oligomers are responsible for such inflammation.
Study examines systematic analysis of brain and retinal samples
In their investigation, the researchers analyzed the relationship between inflammation, toxic tau proteins, and the onset of Alzheimer's disease. For this purpose, the experts use systematic analyzes of brain and retinal samples from people with Alzheimer's and a model with experimental mice.
Toxic dew can cause inflammation in Alzheimer's
The results showed that the toxic tau can cause inflammation in Alzheimer's. The protein spreads between connected brain regions, which can then trigger inflammation in the new regions. This situation can create a cycle of toxic tau oligomer spread, inflammation, and cell death throughout the brain, the scientists explain.
Combined treatment could help prevent Alzheimer's
Our results suggest that neuronal degeneration occurs due to chronic inflammation induced by tau oligomers and could be treated by a combination of anti-tau oligomers and anti-inflammatory therapeutics, explains Rakez Kayed of the University of Texas. (as)