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Muscle wasting in type 1 diabetes should not be neglected
According to researchers, muscle wasting is a problem that is overlooked by diabetics. Maintaining and building up muscles could significantly improve the situation of those affected.
More and more diabetes patients
According to the latest findings, the number of diabetes patients is increasing massively. Many have not known about their illness for a long time. The main risk factors for type 2 diabetes are unhealthy diet, lack of exercise and being overweight or obese. However, these factors do not play a role in type 1 diabetes. According to Canadian scientists, the situation of these patients could also be improved by maintaining and building up muscles.
Maintaining and building muscle can help diabetics
According to researchers at McMaster University in Canada, muscle wasting is a problem that is under-noticed in diabetics. The experts recently published two studies on this subject in the specialist journals “Diabetes” and “Scientific Reports”.
On the internet doctor's platform "esanum" it says that the current treatment of type 1 diabetics focuses not only on dietary measures but also on the replacement of the missing insulin. According to the arguments of the Canadian researchers, the metabolic state of these people could be significantly improved by maintaining and building muscles - in addition to the administration of insulin.
Insulin deficiency has serious consequences
Type 1 diabetes is an immune disease in which the insulin-producing islet cells of the pancreas (pancreas) are destroyed by the body's immune system.
As explained on the online platform, the resulting lack of insulin has a serious impact on the overall metabolic situation. Among other things, the hormone mediates the absorption of glucose in the muscles, which is the largest storage volume for the energy source and thus lowers the glucose level in the blood.
Long-term increased glucose levels
In the early course of the disease there is a loss of muscular stem cells and consequently a decrease in muscle tissue. This has important consequences for glucose metabolism. According to the information, those affected not only suffer from a lack of insulin, but also a loss of storage tissue and thus a reduced absorption capacity for glucose by the target tissues of the insulin.
The result: long-term increased glucose levels, which represent a significant risk factor for a whole range of secondary diseases such as the kidneys or the vascular system.
Pharmaceutical companies are working on better tolerated alternatives
Both in animal experiments and in human studies, the Canadian research team was able to show that measures that prevent the loss of muscle tissue can improve the insulin effect and thus help to reduce the concentration of glucose in the blood in the long term.
In their studies, the scientists used, among other things, active ingredients that inhibit a muscle-own hormone called myostatin, which in turn suppresses muscle growth. According to the study authors, various pharmaceutical companies are currently working on developing better tolerated alternatives to existing agents.
Strengthen muscles naturally
Study author Thomas Hawke of the Michael G. DeGroote School of Medicine at McMaster University said, “While my advice would be to exercise, our work provides potential therapeutic options for those who are unable or unable to do so Are able to train so intensely that therapeutic benefits are shown. "
The authors call on the role of the muscles in the regulation of glucose metabolism not to be neglected and in the treatment of type 1 diabetes to rely more on multidimensional treatment strategies than before. (ad)