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Tripper pathogens mutate: All cures for gonorrhea soon have no effect

Doctors warn: Increasing resistance to antibiotics makes treatment difficult
The so-called gonorrhea is usually colloquially referred to as gonorrhea today. Gonorrhea is one of the most common sexually transmitted diseases. Researchers from the World Health Organization (WHO) have announced that we may soon no longer have effective medication for gonorrhea in the future. There are already fewer and fewer ways to treat the disease effectively.

Scientists at the World Health Organization (WHO) found that gonorrhea is becoming more and more resistant to conventional treatments. The doctors published a new guideline for doctors and those affected. This no longer recommends using so-called quinolones for treatment. This class of antibiotics appears to be becoming increasingly ineffective because various quinolone-resistant strains of the disease have already emerged around the world.

Every year, 78 million people become infected with gonorrhea
The WHO now recommends the use of so-called cephalosporins. This type of antibiotic is currently still effective. The recommendations replace the old guidelines. These were changed in 2003. According to the WHO, about 78 million people are infected with gonorrhea every year.

Super-resistant gonorrhea strain discovered in Japan
The excessive use of antibiotics in other diseases (e.g. urinary tract infections) is unfortunately so widespread that this has led to resistant strains of gonorrhea, the scientists explain. A super-resistant gonorrhea was discovered in Japan in 2011.

Tripper was originally easy to treat with various medications
Gonorrhea has plagued humanity for centuries. Since penicillin has been available, we only need some of the antibiotic to treat the disease. The tripper pathogens were originally susceptible to penicillin, ampicillin, tetracycline and doxycycline, say the experts. These drugs have been used frequently for treatment.

Strains of gonorrhea are constantly developing new mechanisms for protection
However, the drugs gradually lost their effectiveness. And various newer antibiotics quickly became useless. One reason for this is surely that the gonorrhea bacterium mutates quickly in order to better defend itself against medication, the scientists suspect. This creativity to adapt to new drugs is really incredible. The tribes are always developing new mechanisms to effectively protect themselves from the new drugs, the doctors add.

Some strains are already resistant to the new drug
Switching to a new class of antibiotics will not solve the problem of bacterial creativity, the authors explain. In some countries, gonorrhea strains are already resistant to the new class of drugs. Other studies have warned that the spread of the dangerous gonorrhea strain is continuing.

Dual therapy currently in use could also soon become ineffective
Already in 2012, the U.S. Centers for Disease Control and Prevention (CDC) that cephalosporins are ineffective in treating gonorrhea. The experts working there demanded that doctors no longer prescribe cephalosporins. Since then, the recommended treatment for CDC has been dual therapy. This uses ceftriaxone and azithromycin. But an analysis in June warned that this combination could also soon become ineffective.

We urgently need new drugs in five years at the latest
What will happen if antibiotics stop working at all? We will urgently need new drugs in five years at the latest, says Teodora Wi from the Department of Reproductive Health and Research at the WHO. Because gonorrhea, syphilis and Co. are on the rise.

WHO is also changing guidelines for chlamydia and syphilis
The WHO also revised its guidelines for the treatment of two other sexually transmitted infections. So-called chlamydia and syphilis have not yet developed serious antibiotic resistance. For example, syphilis can be treated with a single dose of penicillin. Unfortunately, there is a worldwide shortage of this drug.

Most sexually transmitted infections are more dangerous for women
Although all three sexually transmitted diseases affect both men and women, they can have particularly devastating effects on women, the doctors say. If left untreated, gonorrhea can cause pelvic inflammatory disease and lead to dangerous ectopic pregnancies. Syphilis can spread from a pregnant woman to her child. Chlamydia makes pregnancy less likely, the experts explain. (as)

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