Lack of sleep affects women and men differently

Lack of sleep affects women and men differently

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Lack of sleep with different effects on the enzyme activity of DPP-4

Many people suffer from sleep disorders. The lack of sleep obviously has a very different effect on women and men. According to a recent study, women show a significantly stronger increase in the enzyme activity of DPP-4 than men. The enzyme is associated with the development of obesity, fatty liver and insulin insensitivity.

In a joint study, scientists from the University of Uppsala (Sweden) and the German Institute for Nutritional Research (DifE) demonstrated that women and men react differently to enzyme activity when they lose sleep. Accordingly, women produce more DPP-4, while in men the morning activity of the enzyme drops. The results of the study were published in the specialist magazine "Diabetes Care".

Lack of sleep increases the risk of diabetes and obesity

In previous studies, sleep disorders were identified as risk factors for obesity and type 2 diabetes. Increased formation of the enzyme DPP-4, which inhibits important intestinal hormones of the sugar metabolism, can in turn lead to an increase in body fat, fatty liver and insulin insensitivity, according to various studies by the DIfE. So far, however, it has remained unclear whether lack of sleep affects the activity of DPP-4, the scientists report.

Significant differences in enzyme activity

In the current study, the researchers "measured the activity of DDP-4 in the blood in 13 women and 12 men (ages 18-28 years) in the morning after a normal night's sleep (with seven hours of sleep and more) or a night without sleep" , reports the German Center for Diabetes Research, a partner of DifE. In their investigation, the scientists were able to identify significant differences in DPP-4 activity between the sexes. According to Christian Benedict, senior author and research associate at Uppsala University's Sleep and Chronobiology department, circulatory DPP-4 increased in women by about 14 percent after a sleepless night, while in men it increased by about 11 percent Percent dropped.

Men also show an increased risk of getting sick if they lack sleep

The scientists believe that lack of sleep in men and women can lead to a metabolic disorder in different ways. Because in both men the risk of a metabolic disease is increased by sleep disorders. "Although reduced DPP-4 can be seen as a favorable metabolic response by men to sleep loss, it should be noted that chronically poor sleep patterns increase the risk of developing metabolic diseases (eg obesity) in both sexes," emphasizes Heike Vogel from the Experimental Department Diabetology of DifE. (fp)

Author and source information

Video: Study: Women more affected by sleep deprivation (May 2022).


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